Ashok Jadhav Selected Research

Hemin (Panhematin)

1/2014	Hemin therapy improves kidney function in male streptozotocin-induced diabetic rats: role of the heme oxygenase/atrial natriuretic peptide/adiponectin axis.
1/2014	The heme oxygenase system suppresses perirenal visceral adiposity, abates renal inflammation and ameliorates diabetic nephropathy in Zucker diabetic fatty rats.
5/2013	The heme oxygenase system selectively enhances the anti-inflammatory macrophage-M2 phenotype, reduces pericardial adiposity, and ameliorated cardiac injury in diabetic cardiomyopathy in Zucker diabetic fatty rats.
1/2013	The risk of heart failure and cardiometabolic complications in obesity may be masked by an apparent healthy status of normal blood glucose.
1/2013	The heme oxygenase system rescues hepatic deterioration in the condition of obesity co-morbid with type-2 diabetes.
2/2010	Up-regulating the heme oxygenase system with hemin improves insulin sensitivity and glucose metabolism in adult spontaneously hypertensive rats.
1/2010	The heme oxygenase system attenuates pancreatic lesions and improves insulin sensitivity and glucose metabolism in deoxycorticosterone acetate hypertension.
9/2009	Upregulating the heme oxygenase system suppresses left ventricular hypertrophy in adult spontaneously hypertensive rats for 3 months.
6/2009	Up-regulating the hemeoxygenase system enhances insulin sensitivity and improves glucose metabolism in insulin-resistant diabetes in Goto-Kakizaki rats.
5/2009	Upregulation of the heme oxygenase system ameliorates postprandial and fasting hyperglycemia in type 2 diabetes.

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Ashok Jadhav Research Topics

Disease

9	Hypertension (High Blood Pressure) 01/2013 - 01/2007
9	Fibrosis (Cirrhosis) 01/2013 - 06/2008
8	Hyperglycemia 01/2014 - 04/2009
8	Inflammation (Inflammations) 01/2014 - 06/2008
8	Insulin Resistance 01/2013 - 04/2009
7	Hypertrophy 05/2013 - 11/2008
5	Proteinuria 01/2014 - 03/2009
5	Albuminuria 01/2014 - 03/2009
5	Cardiomegaly (Heart Hypertrophy) 05/2013 - 11/2008
5	Hyperaldosteronism (Conn Syndrome) 12/2012 - 06/2008
3	Necrosis 01/2014 - 04/2009
3	Obesity 05/2013 - 01/2013
3	Cicatrix (Scar) 09/2009 - 11/2008
2	Diabetic Nephropathies (Diabetic Nephropathy) 01/2014 - 01/2014
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2014 - 04/2009
2	Essential Hypertension 02/2010 - 06/2008
2	Edema (Dropsy) 01/2010 - 04/2009
2	Body Weight (Weight, Body) 09/2009 - 11/2008
2	Type 2 Diabetes Mellitus (MODY) 05/2009 - 05/2009
1	Gangrene 01/2021
1	Stroke (Strokes) 01/2016
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2016
1	Vascular Diseases (Vascular Disease) 01/2016
1	Atherosclerosis 01/2016
1	Kidney Diseases (Kidney Disease) 01/2014
1	Diabetic Cardiomyopathies 05/2013
1	Non-alcoholic Fatty Liver Disease 01/2013
1	Heart Failure 01/2013
1	Chronic Kidney Failure (Chronic Renal Failure) 07/2010
1	Glucose Intolerance 02/2010
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 02/2010
1	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 09/2009

Drug/Important Bio-Agent (IBA)

17	Heme Oxygenase (Decyclizing) (Heme Oxygenase)IBA 01/2014 - 01/2007
15	Hemin (Panhematin)FDA Link 01/2014 - 06/2008
11	Proteins (Proteins, Gene)FDA Link 01/2014 - 11/2008
9	Insulin (Novolin)FDA Link 05/2013 - 04/2009
9	Glucose (Dextrose)FDA LinkGeneric 05/2013 - 04/2009
8	Fibronectins (Fibronectin)IBA 01/2014 - 11/2008
7	CollagenIBA 01/2014 - 11/2008
7	AdiponectinIBA 01/2014 - 04/2009
7	Desoxycorticosterone (Deoxycorticosterone)IBA 12/2012 - 06/2008
7	Acetates (Acetic Acid Esters)FDA Link 12/2012 - 06/2008
7	NF-kappa B (NF-kB)IBA 04/2010 - 06/2008
6	SaltsIBA 12/2012 - 06/2008
6	Desoxycorticosterone Acetate (DOCA)FDA Link 12/2012 - 06/2008
5	Hypoglycemic Agents (Hypoglycemics)IBA 01/2014 - 04/2009
5	AldosteroneIBA 01/2014 - 01/2007
5	chromium mesoporphyrinIBA 01/2014 - 11/2008
5	AntioxidantsIBA 07/2010 - 11/2008
4	CreatinineIBA 01/2014 - 03/2009
4	Transcription Factor AP-1 (Transcription Factor AP 1)IBA 05/2013 - 11/2008
4	8-epi-prostaglandin F2alphaIBA 05/2013 - 07/2009
4	heme arginateIBA 12/2012 - 07/2009
3	Atrial Natriuretic Factor (ANF)IBA 01/2014 - 07/2010
3	Interleukin-6 (Interleukin 6)IBA 01/2014 - 01/2013
3	stannous mesoporphyrinIBA 05/2013 - 01/2013
3	MineralocorticoidsIBA 07/2010 - 03/2009
3	Ferritins (Ferritin)IBA 07/2009 - 03/2009
2	CholesterolIBA 01/2016 - 01/2013
2	Extracellular Matrix ProteinsIBA 01/2014 - 11/2008
2	CytokinesIBA 01/2014 - 05/2013
2	Endothelins (Endothelin)IBA 05/2013 - 12/2012
2	OsteopontinIBA 01/2013 - 01/2013
2	Transforming Growth Factor beta (TGF-beta)IBA 07/2010 - 07/2009
2	AMP-Activated Protein KinasesIBA 02/2010 - 05/2009
2	Type C PhospholipasesIBA 09/2009 - 06/2008
2	Phosphotransferases (Kinase)IBA 07/2009 - 11/2008
2	BilirubinIBA 05/2009 - 03/2009
2	Transcription Factors (Transcription Factor)IBA 03/2009 - 11/2008
1	Adrenergic Agents (Adrenergic Drugs)IBA 01/2021
1	Ergot AlkaloidsIBA 01/2021
1	secoisolariciresinol diglucosideIBA 01/2016
1	Dietary CholesterolIBA 01/2016
1	Linseed Oil (Flaxseed Oil)IBA 01/2016
1	LDL CholesterolIBA 01/2016
1	LignansIBA 01/2016
1	IonsIBA 01/2014
1	nephrinIBA 01/2014
1	Interleukin-10 (Interleukin 10)IBA 01/2014
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2013
1	Insulin ReceptorIBA 05/2013
1	InterleukinsIBA 05/2013
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 05/2013
1	JNK Mitogen-Activated Protein KinasesIBA 05/2013
1	OsteoprotegerinIBA 01/2013
1	Blood Glucose (Blood Sugar)IBA 01/2013
1	Calcineurin InhibitorsIBA 01/2013
1	Macrophage Inflammatory Proteins (Macrophage Inflammatory Protein 1)IBA 01/2013
1	Chemotactic FactorsIBA 01/2013
1	Triglycerides (Triacylglycerol)IBA 01/2013
1	Endothelin-1 (Endothelin 1)IBA 07/2010
1	EnzymesIBA 09/2009
1	Guanosine Monophosphate (5' Guanylic Acid)IBA 07/2009
1	Fructose-Bisphosphate Aldolase (Aldolase)IBA 05/2009
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 05/2009
1	3-nitrotyrosineIBA 05/2009
1	Streptozocin (Streptozotocin)FDA Link 04/2009
1	IronIBA 03/2009

Therapy/Procedure

8	Therapeutics 01/2014 - 11/2008
1	Complementary Therapies (Alternative Medicine) 01/2016